NorthenLab: Exometabolomics linking genomes with environments to understand how webs of microbes sustain biomes
Noel Ha

Noel Ha

Post-Doctoral Researcher

High-throughput screening of metabolites and enzyme activity via microfluidics

Combinatorial screening of massive scale enzyme libraries through metabolite detection has the potential to discover new enzymes and multi-step metabolic pathways. I am developing a novel droplet microfluidic device that can be directly coupled with a nanostructure-initiator mass spectrometry (NIMS), to create a new approach for rapid screening of enzyme activities at a massive scale up to 100,000 metabolite analyses on a single microfluidic chip. We envision broad applications of this microfluidic system in discovery of new enzymes to support synthetic biology and biomass deconstruction as well as drug development.






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