Increasing throughput: developing high throughput mass spectrometry-based assays
Traditional LC/GC-MS methods are often low-throughput. Nanostructure-initiator mass spectrometry (NIMS) presents a powerful alternative to standard LC/GC-MS methods. NIMS has extremely high sensitivity and lateral resolution, which allows the disposition and analysis of ~10,000 samples. I am developing novel high-throughput mass spectrometry assays by integrating nanoscale sample deposition methods into NIMS. I apply these assays, for example, on activity screening of peptoid/peptide libraries and small molecule uptake/synthesis in microbial/cellular systems.