Here we highlight current high-throughput MS-based platforms and their potential application in metabolomics. Although current MS platforms can reach throughputs up to 0.5 seconds per sample, the metabolite coverage of these platforms are low compared to low-throughput, separation-based MS methods. High-throughput comes at a cost, as it’s a trade-off between sample throughput and metabolite coverage. We discuss promising emerging technologies, including microfluidics and miniaturization of separation techniques, which have the potential to achieve both rapid and more comprehensive metabolite analysis.
The journal article can be found here